Journal of Genetics and Genomics2025年第1期(Volume 52, Issue 1, 2025) 在线发表，迎接各人下载阅读。
下载网址：
https://www.sciencedirect.com/journal/journal-of-genetics-and-genomics/vol/52/issue/1
本期封面
而OPPOFindX8Ultra则定位影像旗舰，搭载超强四摄模组中的主要相机有望采用一英寸超大底传感器，大概是索尼LYT900传感器。潜望式长焦镜头分别采用索尼IMX906和索尼IMX882传感器，支持三倍和六倍的光学变焦。而超广角镜头将采用索尼IMX882传感器。此外，该机还将内置6000mAh容量的硅电池。
话不多说，今天我们就来扒一扒这款去年下半年推出的旗舰小屏机，为啥它能吸引小屏党们的目光。
Volume 52, Issue 1
On the cover: Deciphering spatial domains coherent in gene expression and spatial topology from spatial resolved transcriptomics data is a critical task. However, existing methods often consider only the spatial location relationship between spots or cells, overlooking other potential biological relationships. In this issue, Sun et al. propose SpaGRA, a method combining graph augmentation and geometric contrastive learning that uses multi-head attention to capture multi-level biological interactions and negative sample generation strategy to enhance robustness (pp. 93–104). The cover image shows three distinct spatial domains, analogous to Cao Wei, Shu Han, and Eastern Wu during the Three Kingdoms period in ancient China (AD 220–280). SpaGRA is capable of effectively capturing the border interactions, such as conflict and cooperation, which symbolize the key biological connections among distinctive cell types, significantly improving the accuracy of spatial domain identification.
本期本质简介
Volume 52, Issue 1
Meeting Report
The future of zebrafish research: highlights from the 18th International Zebrafish Conference
Chenyang Bian, Dongyuan Ma, Feng Liu
https://doi.org/10.1016/j.jgg.2024.09.006
中国科学院动物计算所刘峰团队细腻第十八届海外斑马鱼大会的最新计算效力，并就斑马鱼范围的将来发展进行预计，强调高分辨率成像技艺及多组学技艺的平方利用。
Review
Crop root system architecture in drought response
Yanjun Zhang, Xi Wu, Xingrong Wang, Mingqiu Dai, Yunling Peng
https://doi.org/10.1016/j.jgg.2024.05.001
甘肃农业大学彭云玲团队、华中农业大学代明球团队和甘肃省农业科学院作物计算所王兴荣团队息争综述干旱威胁下作物根绑缚构的遗传调控荟萃，详尽作物抗旱性的联想根绑缚构特征，猜想打行为物根绑缚构更正战术过头在作物抗旱遗传更正和抗旱育种上头对的挑战以及将来计算见识。
The interplay between extracellular and intracellular auxin signaling in plants
Wenxin Tang, Yongqiang Yu, Tongda Xu
https://doi.org/10.1016/j.jgg.2024.06.019
福建农林大学徐邃晓素养团队综述细腻孕育素生物学功能特色，先容了胞外和胞内孕育素信号通路的构成，重心讲演了胞外和胞内孕育素信号通路在植物多个紧迫生物学经由中的交互调控作用。
The interplay between histone modifications and nuclear lamina in genome regulation
Chang Sun, Yanjing Zhao, Liping Guo, Juhui Qiu, Qin Peng
https://doi.org/10.1016/j.jgg.2024.10.005
深圳湾实验室系统与物理生物学计算所彭琴和重庆大学生物工程学院邱菊辉团队息争综述染色质修饰与核纤层在基因组转录调控中的相互作用，并研讨了它们在细胞分化中的调控作用及在疾病维持中的潜在利用。
Original Research
KDM2A and KDM2B protect a subset of CpG islands from DNA methylation
Yuan Liu, Ying Liu, Yunji Zhu, Di Hu, Hu Nie, Yali Xie, Rongrong Sun, Jin He, Honglian Zhang, Falong Lu
https://doi.org/10.1016/j.jgg.2024.10.012
中国科学院遗传与发育生物学计算所陆发隆计算员团队揭示KDM2A和KDM2B卵白协同调控哺乳动物基因组中部分CpG岛低甲基化气象的分子机制，为哺乳动物基因组中总体DNA甲基化样式设立与防守提供新视力。
Rab1 and Syntaxin 17 regulate hematopoietic homeostasis through β-integrin trafficking inDrosophila
Fangzhou Luo, Luwei Sui, Ying Sun, Zhixian Lai, Chengcheng Zhang, Gaoqun Zhang, Bing Bi, Shichao Yu, Li Hua Jin
https://doi.org/10.1016/j.jgg.2024.11.001
东北林业大学金丽华素养团队揭示了果蝇小GTP酶Rab1和Qa-SNARE卵白Syx17通过退换β-integrin的囊泡转运防守造血作用稳态，为计算造血干细胞的非自主退换机制提供新想路。
Prox1a promotes liver growth and differentiation by repressingcdx1bexpression and intestinal fate transition in zebrafish
Yingying Hu, Zhou Luo, Meiwen Wang, Zekai Wu, Yunxing Liu, Zhenchao Cheng, Yuhan Sun, Jing-Wei Xiong, Xiangjun Tong, Zuoyan Zhu, Bo Zhang
https://doi.org/10.1016/j.jgg.2024.09.010
北京大学生命科学学院张博素养团队揭示了Prox1a通过扼制肝脏细胞向肠谈运谈分化调控斑马鱼肝脏发育的新机制，为意会Prox1在脊椎动物肝脏发育中的重要作用以及探究同源异形盒家眷基因间的功能相互作用提供了新想路。
Epigenetic basis for the establishment of ruminal tissue-specific functions in bovine fetuses and adults
Jing Wang, Wen Yuan, Fang Liu, Guangbo Liu, Xiaoxiong Geng, Chen Li, Chenchen Zhang, Nan Li, Xueling Li
https://doi.org/10.1016/j.jgg.2024.10.008
内蒙古大学李雪玲计算员团队通过多组学分析揭示牛瘤胃组织特异性各异甲基化区域对其发育和功能设立的调控机制，DNA甲基化不错通过远端增强子退换瘤胃上皮发育及酮体代谢，为反刍动物表不雅基因组学计算提供新视角。
Method
SpaGRA: Graph augmentation facilitates domain identification for spatially resolved transcriptomics
Xue Sun, Wei Zhang, Wenrui Li, Na Yu, Daoliang Zhang, Qi Zou, Qiongye Dong, Xianglin Zhang, Zhiping Liu, Zhiyuan Yuan, Rui Gao
https://doi.org/10.1016/j.jgg.2024.09.015
山东大学拆伙科学与工程学院高瑞素养团队和复旦大学类脑智能科学与技艺计算院原致远后生副计算员合营迷惑了一个新的空间域识别体式SpaGRA (
https://github.com/sunxue-yy/SpaGRA)。该体式偶然通过图增强算法罢了多重联系的自动构建，挖掘SRT数据中细胞间潜在的多档次联系，从而改进空间域的识别效果，为基于SRT的空间结构域预测提供了新的想路(封面论文)。
Improving precision base editing of the zebrafish genome by Rad51DBD-incorporated single-base editors
Zhilin Zhong, Xueli Hu, Renjie Zhang, Xu Liu, Wenqi Chen, Shubin Zhang, Jianjian Sun, Tao P. Zhong
https://doi.org/10.1016/j.jgg.2024.10.006
华东师范大学生命科学学院钟涛素养团队构建带有单链DNA联结卵白Rad51DBD的超高活性胞嘧啶碱基剪辑器zhyA3A-CBE5，在斑马鱼中展示出更强的C-T剪辑活性和更宽的剪辑窗口，在东谈主类遗传疾病点突变的构建方面具有彰着上风。该计算膨大了斑马鱼基因组碱基剪辑平台，增强了单碱基剪辑器在疾病模子和基因功能计算中的利用。
Research Communications
Pan-genome analyses add ∼1000 genes to the “complete” genome assembly of chicken
Jilong Ren, Wenyan Kou, Yuan Xu, Meixuan Lu, Mian Gong, Xinmiao Zhang, Zhenyu Liu, Hengkuan Li, Qimeng Yang, Ali Mujtaba Shah, Feng Zhu, Zhuocheng Hou, Naiyi Xu, Yu Jiang, Fei Wang
https://doi.org/10.1016/j.jgg.2024.10.009
西北农林科技大学姜雨素养团队基于鸡GRCg7b和GGswu1两个参考基因组构建愈加完善的鸡泛基因组，区分已然到了208.1 Mb和170.3 Mb的新序列，防护到1242和880个新基因，为家禽的功能基因组学计算提供愈加竣工的基因邻接。
TaNPF6.2 improves agronomic traits via enhancing nitrogen uptake efficiency in wheat
Huanhuan Wang, Yangyang Liu, Lifen Wu, Chuan Xia, Yaoyu Chen, Xiuying Kong, Feng Shi, Huili Li, Xifang Yang, Liang Ma, Jiaqiang Sun, Lichao Zhang, Zhencheng Xie
https://doi.org/10.1016/j.jgg.2024.11.004
中国农业科学院作物科学计算所小麦产量性状分解与瞎想团队分解TaNPF6.2通过普及小麦氮素吸见效力改善农艺性状(如增多分蘖数、穗长、穗粒数和千粒重等)的分子机制，为小麦绿色高产育种提供了新的候选基因。
Zebrafish cartilage development atlas generated by longitudinal in vivo imaging
Shirong Jin, Hongfei Zhang, Jia Li, Huaxing Zi, Jiulin Du, Hongyu Li
https://doi.org/10.1016/j.jgg.2024.11.003
中国科学院脑科学与智能技艺超卓改进中心杜久林计算员团队通过象征内源性邻接卵白聚糖A (Aggrecan A, acana)澳门六合彩论坛高手，构建了斑马鱼年少期全身软骨发育图谱，为计算软骨发育提供了可视化资源。